http://kadhoai.com.cn 2026-04-26 15:50:17 來源:生物穀
新式的超靈敏生物傳感器,可以對癌症和病人個性化用藥涉及的生化反應進行早期及時檢測 (Credit: Purdue University image)
jinri,laizipududaxuedeyanjiuzhefamingleyizhongchaolingmindeshengwuchuanganqi,keyiduiaizhenghebingrengexinghuayongyaoshejideshenghuafanyingjinxingzaoqijishijiance。zhezhongshengwuchuanganqijieheleliangzhongbutongleixingdechuanganqi,biyibandechuanganqimingandugaoshubaibei。yanjiuzheMuhammad A.Alam表biao示shi,一yi般ban來lai講jiang,單dan獨du的de不bu同tong類lei型xing的de生sheng物wu傳chuan感gan器qi的de檢jian測ce敏min感gan性xing會hui有you一yi定ding限xian製zhi,但dan是shi如ru果guo將jiang其qi結jie合he起qi來lai,就jiu會hui克ke服fu其qi敏min感gan性xing上shang的de限xian製zhi。相xiang關guan研yan究jiu成cheng果guo刊kan登deng在zai了le5月14日的國際雜誌PNAS上。
這種名叫Flexure-FET的de生sheng物wu傳chuan感gan器qi結jie合he了le一yi個ge機ji械xie傳chuan感gan器qi和he電dian子zi傳chuan感gan器qi,前qian者zhe可ke以yi識shi別bie出chu生sheng物wu活huo性xing分fen子zi的de分fen子zi量liang以yi及ji尺chi寸cun,電dian子zi傳chuan感gan器qi可ke以yi利li用yong電dian荷he來lai對dui分fen子zi進jin行xing鑒jian定ding,這zhe種zhong新xin式shi傳chuan感gan器qi可ke以yi對dui帶dai電dian荷he和he不bu帶dai電dian荷he的de生sheng物wu分fen子zi進jin行xing檢jian測ce,比bi一yi般ban的de傳chuan感gan器qi的de檢jian測ce範fan圍wei更geng廣guang。Flexure-FET有兩種潛在的應用前景,1.個體化醫療,可以精確記錄病人的蛋白質和DNA信息,並且提供更為精確的診斷和治療建議;2.癌症和其它疾病的早期檢測。

在早期癌症診斷中,Flexure-FET可以在疾病被其它檢測設備檢測到之前,對疾病前期少量的DNA片段和蛋白質進行必要可能的檢測,傳感器的機械部分是一個振動懸臂(和微小跳水板類似的矽片),在zai懸xuan臂bi底di下xia的de是shi一yi個ge電dian晶jing片pian,是shi傳chuan感gan器qi的de電dian子zi部bu分fen。在zai其qi它ta的de機ji械xie傳chuan感gan器qi中zhong,激ji光guang可ke以yi測ce定ding振zhen動dong頻pin率lv和he懸xuan臂bi的de偏pian斜xie度du,並bing且qie依yi賴lai生sheng物wu分fen子zi的de類lei型xing而er改gai變bian,然ran而er這zhe種zhong新xin式shi傳chuan感gan器qi僅jin僅jin使shi用yong電dian晶jing片pian來lai測ce定ding振zhen動dong頻pin率lv和he懸xuan臂bi的de偏pian斜xie度du。
這zhe種zhong新xin式shi的de生sheng物wu傳chuan感gan器qi可ke以yi通tong過guo調tiao整zheng整zheng體ti結jie構gou來lai使shi得de檢jian測ce靈ling敏min度du達da到dao最zui大da,懸xuan臂bi是shi用yong電dian場chang來lai進jin行xing牽qian引yin的de,而er電dian晶jing片pian依yi賴lai於yu電dian壓ya來lai調tiao節jie其qi靈ling敏min度du,研yan究jiu者zheAlam表biao示shi,你ni可ke以yi用yong任ren何he你ni能neng想xiang到dao的de分fen子zi來lai進jin行xing檢jian測ce,傳chuan感gan器qi都dou會hui給gei出chu你ni最zui精jing確que的de測ce定ding結jie果guo。這zhe項xiang新xin技ji術shu的de關guan鍵jian創chuang新xin點dian在zai於yu消xiao除chu了le參can比bi電dian極ji的de限xian製zhi,然ran而er常chang規gui的de生sheng物wu傳chuan感gan器qi卻que是shi需xu要yao參can比bi電dian極ji的de。最zui後hou研yan究jiu者zhe表biao示shi,消xiao除chu了le參can比bi電dian極ji可ke以yi使shi得de生sheng物wu傳chuan感gan器qi更geng加jia小xiao型xing化hua,而er且qie因yin其qi低di成cheng本ben和he實shi用yong性xing,對dui於yu廣guang大da醫yi生sheng來lai說shuo更geng為wei實shi用yong並bing且qie可ke行xing。(生物穀:T.Shen編譯)